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Advanced Photonics Laboratory

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 > Abstract: A diabetic wound presents a severe risk of infections and other complications because of its
> slow healing. Evaluating the pathophysiology during wound healing is imperative for wound care,
> necessitating a proper diabetic wound model and assay for monitoring. The adult zebrafish is a rapid
> and robust model for studying human cutaneous wound healing because of its fecundity and high
> similarities to human wound repair. OCTA as an assay can provide three-dimensional (3D) imaging
> of the tissue structure and vasculature in the epidermis, enabling monitoring of the pathophysiologic
> alterations in the zebrafish skin wound. We present a longitudinal study for assessing the cutaneous
> wound healing of the diabetic adult zebrafish model using OCTA, which is of importance for the
> diabetes research using the alternative animal models. We used non-diabetic (n = 9) and type 1
> diabetes mellitus (DM) adult zebrafish models (n = 9). The full-thickness wound was generated on
> the fish skin, and the wound healing was monitored with OCTA for 15 days. The OCTA results
> demonstrated significant differences between diabetic and non-diabetic wound healing, involving
> delayed tissue remodeling and impaired angiogenesis for the diabetic wound, leading to slow wound
> recovery. The adult zebrafish model and OCTA technique may benefit long-term metabolic disease
> studies using zebrafish for drug development.
 > 
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